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Chemical Structure : Pitstop 2
Catalog No.: PC-60190Not For Human Use, Lab Use Only.
Pitstop 2 is a small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.
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Pitstop 2 is a small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.
Pitstop 2 inhibits endocytosis of transferrin receptor, a CDE cargo protein, but not affect endocytosis of shiga toxin.
Pitstop 2 traps HeLa cells in metaphase through loss of mitotic spindle integrity and activation of the spindle assembly checkpoint.
Pitstop 2 is a useful tool for investigating clathrin spindle dynamics.
| M.Wt | 473.36 | |
| Formula | C20H13BrN2O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dutta D, et al. PLoS One. 2012;7(9):e45799.
2. Smith CM, et al. Mol Cancer. 2013 Jan 17;12:4.
3. Liashkovich I, et al. Sci Rep. 2015 May 6;5:9994.
4. Willox AK, et al. Biol Open. 2014 Apr 4;3(5):326-31.
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