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Pleconaril

Chemical Structure : Pleconaril

CAS No.: 153168-05-9

Pleconaril (Picovir;VP-63843;Win-63843)

Catalog No.: PC-45760Not For Human Use, Lab Use Only.

Pleconaril (Picovir, VP-63843, Win-63843) is a broad spectrum antipicornaviral agent that inhibits rhinovirus replication by interaction with the VP1 protein.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pleconaril (Picovir, VP-63843, Win-63843) is a broad spectrum antipicornaviral agent that inhibits rhinovirus replication by interaction with the VP1 protein; inhibits EV-D68 with EC50 of 430 nM; shows active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.

Rhinovirus Infection

Phase 2 Clinical

Physicochemical Properties

M.Wt 381.349
Formula C18H18F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2,4-Oxadiazole, 3-[3,5-dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-

References

1. Florea NR, et al. Pharmacotherapy. 2003 Mar;23(3):339-48.

2. Pevear DC, et al. Antimicrob Agents Chemother. 1999 Sep;43(9):2109-15.

3. Liu Y, et al. Science. 2015 Jan 2;347(6217):71-4.

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