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Pterostilbene

Chemical Structure : Pterostilbene

CAS No.: 537-42-8

Pterostilbene

Catalog No.: PC-62610Not For Human Use, Lab Use Only.

Pterostilbene is a natural phenolic compound, dimethylated derivative of resveratrol that has potent antitumor activity against several human cancer types.

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Biological Activity

Pterostilbene is a natural phenolic compound, dimethylated derivative of resveratrol that has potent antitumor activity against several human cancer types; induces strong and sustained activation of ERK1/2, with concomitant cyclin D1 suppression and p21 up-regulation, and inhibits the phosphorylation of AKT and mTOR in MDA-MB-468 cells; synergizes the antineoplastic effects of megestrol acetate in endometrial cancer; also targets MTA1/HDAC signaling with deacetylation of tumor suppressors p53 and PTEN in prostate cancer cells.

Physicochemical Properties

M.Wt 256.301
Formula C16H16O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Stilbenol, 3',5'-dimethoxy-, (E)- (8CI)

References

1. Chatterjee K, et al. Nutrients. 2018 Feb 21;10(2). pii: E243.

2. Butt NA, et al. Cancer Med. 2017 Nov;6(11):2673-2685.

3. Wakimoto R, et al. Anticancer Res. 2017 Nov;37(11):6153-6159.

4. Wen W, et al. Sci Rep. 2017 Oct 6;7(1):12754.

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