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Chemical Structure : RAS inhibitor Abd-7
Catalog No.: PC-35587Not For Human Use, Lab Use Only.
RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling.
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RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling; impairs the protein-protein interaction (PPI) of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRASQ61H and HRASG12V, inhibits phosphorylation of both downstream biomarkers in colorectal cancer (DLD-1, KRASG13D) and NSCLC (H538, KRASG12C) human cell lines, with reduction of AKT phosphorylation starting at 2 uM; shows consistent inhibitory effects in the cell-based BRET assay and the biomarker assay.
| M.Wt | 391.471 | |
| Formula | C23H25N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quevedo CE, et al. Nat Commun. 2018 Aug 9;9(1):3169.
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