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RO6889678

Chemical Structure : RO6889678

CAS No.: 1578153-27-1

RO6889678 (RO 6889678)

Catalog No.: PC-62578Not For Human Use, Lab Use Only.

RO6889678 is a highly potent inhibitor of HBV capsid formation with attributes that are favorable for targeting the liver, whilst maintaining moderate peripheral exposure..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RO6889678 is a highly potent inhibitor of HBV capsid formation with attributes that are favorable for targeting the liver, whilst maintaining moderate peripheral exposure.

HBV Infection

Phase 1 Discontinued

Physicochemical Properties

M.Wt 494.922
Formula C21H20ClFN4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid

References

1. Kratochwil NA, et al. J Pharmacol Exp Ther. 2018 Feb 16. pii: jpet.117.245712.

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