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Chemical Structure : Ronacaleret
CAS No.: 753449-67-1
Catalog No.: PC-61505Not For Human Use, Lab Use Only.
Ronacaleret (SB751689) is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.
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|---|---|---|---|
| 5 mg | $488 | In stock | |
| 10 mg | $788 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Ronacaleret (SB751689) is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.
Ronacaleret (SB751689) stimulates parathyroid hormone (PTH) release and increases bone formation markers.
Ronacaleret (SB751689) act as an effective oral anabolic agent to enhance fracture healing.
| M.Wt | 447.523 | |
| Formula | C25H31F2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[3-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]-4,5-difluorophenyl]propanoic acid |
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1. Balan G, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32.
2. Fitzpatrick LA, et al. J Clin Endocrinol Metab. 2011 Aug;96(8):2441-9.
3. Fitzpatrick LA, et al. Bone. 2011 Oct;49(4):845-52.
4. Caltabiano S, et al. Bone. 2013 Sep;56(1):154-62.
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