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Chemical Structure : Roxadustat
CAS No.: 808118-40-3
Catalog No.: PC-43531Not For Human Use, Lab Use Only.
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $148 | In stock | |
| 500 mg | $278 | In stock | |
| 1 g | Get quote |
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Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
FG-4592 stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, demonstrates potential for treatment of anemia.
| M.Wt | 352.3407 | |
| Formula | C19H16N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]- |
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1. Besarab A, et al. J Am Soc Nephrol. 2016 Apr;27(4):1225-33.
2. Wu Y, et al. J Med Chem. 2018 Jun 28;61(12):5332-5349.
3. Provenzano R, et al. Clin J Am Soc Nephrol. 2016 Jun 6;11(6):982-91.
4. Jain IH, et al. Science. 2016 Apr 1;352(6281):54-61.
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