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Chemical Structure : Rupintrivir
CAS No.: 223537-30-2
Catalog No.: PC-63345Not For Human Use, Lab Use Only.
Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.
Rupintrivir (AG-7088) potently and irreversibly inhibits HRV 3C protease with an inactivation rate constant (kobs/[I]) of 1,470,000 ± 440,000 M-1 s-1 for HRV 14.
Rupintrivir (AG-7088) also potently inhibits related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11.
| M.Wt | 598.672 | |
| Formula | C31H39FN4O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate |
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1. Patick AK, et al. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50.
2. Dragovich PS, et al. J Med Chem. 1999 Apr 8;42(7):1213-24.
3. Matthews DA, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7.
4. Zalman LS, et al. Antimicrob Agents Chemother. 2000 May;44(5):1236-41.
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