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Chemical Structure : SAK3
Catalog No.: PC-36028Not For Human Use, Lab Use Only.
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro.
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SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of naïve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.
| M.Wt | 369.421 | |
| Formula | C20H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yabuki Y, et al. Neuropharmacology. 2017 May 1;117:1-13.
2. Izumi H, et al. Neuroscience. 2018 May 1;377:87-97.
3. Husain N, et al. Pharmacology. 2018;101(5-6):309-321.
4. Wang S, et al. PLoS One. 2018 Dec 20;13(12):e0206986.
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