Chemical Structure : SAR-020106
Catalog No.: PC-60311Not For Human Use, Lab Use Only.
A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM.
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A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM; brogates the etoposide-induced G(2) arrest with IC50 of 55 nM in HT29 cells, significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro; inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 both in vitro and in vivo; enhances irinotecan and gemcitabine antitumor activity in mice with minimal toxicity.
M.Wt | 382.85 | |
Formula | C19H19ClN6O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Walton MI, et al. Mol Cancer Ther. 2010 Jan;9(1):89-100.
2. Reader JC, et al. J Med Chem. 2011 Dec 22;54(24):8328-42.
3. Borst GR, et al. Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1110-8.
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