Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SB-435495
Catalog No.: PC-63003Not For Human Use, Lab Use Only.
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM; inhibits the enzyme in whole human plasma with IC50 of 3 nM; shows little interaction with other CYP450 enzymes (CYP450 IC50: 1A2>100 mM, 2C9>100 uM, 2C19>40 uM, 2D6=37 uM); effectively suppresses BRB breakdown in streptozotocin-diabetic Brown Norway rats,.
Atherosclerosis
Phase 2 Discontinued
| M.Wt | 720.832 | |
| Formula | C38H40F4N6O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Blackie JA, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6.
2. Canning P, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7213-8.
3. Tyurin VA, et al. Cell Death Differ. 2014 May;21(5):825-35.
4. Jiang Z, et al. Respir Res. 2012 Nov 12;13:100.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
