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Chemical Structure : SB-743921
CAS No.: 940929-33-9
Catalog No.: PC-42882Not For Human Use, Lab Use Only.
SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $878 | In stock | |
| 500 mg | Get quote |
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SB-743921 is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E; also shows high affinity for mouse KSP with Ki of 0.12 nM; blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death in cancer cells, demonstrates improved potency over ispinesib in both biochemical and cellular assays; shows a broad spectrum of tumor inhibition in multiple cancer models.
Blood Cancer
Phase 2 Discontinued
| M.Wt | 553.5193 | |
| Formula | C31H34Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-, hydrochloride (1:1) |
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1. Good JA, et al. J Med Chem. 2013 Mar 14;56(5):1878-93.
2. Holen KD, et al. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54.
3. Zhu L, et al. Anticancer Drugs. 2016 Oct;27(9):863-72.
4. Talapatra SK, et al. J Med Chem. 2013 Aug 22;56(16):6317-29.
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