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Chemical Structure : SCYX-7158
CAS No.: 1266084-51-8
Catalog No.: PC-60316Not For Human Use, Lab Use Only.
SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent.
SCYX-7158 is active in vitro against relevant strains of Trypanosoma brucei, including T. b. rhodesiense and T. b. gambiense.
SCYX-7158 is efficacious in both stage 1 and stage 2 murine HAT models and has good physicochemical and ADMET properties for the treatment of stage 2 human African trypanosomiasis.
| M.Wt | 367.102 | |
| Formula | C17H14BF4NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-(trifluoromethyl)benzamide |
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1. Jacobs RT, et al. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151.
2. Jacobs RT, et al. Future Med Chem. 2011 Aug;3(10):1259-78.
3. Wring S, et al. Parasitology. 2014 Jan;141(1):104-18.
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