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Chemical Structure : SG3199
Catalog No.: PC-35367Not For Human Use, Lab Use Only.
SG3199 (SG-3199) is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM.
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SG3199 (SG-3199) is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM.
SG3199 high-efficiently causes DNA interstrand cross-links in cancer cells。
ADCT-402 (loncastuximab tesirine) is a novel CD19-targeted ADC delivering SG3199, ADCT-402 is highly potent, dose-dependent antitumor activity in several subcutaneous and disseminated human tumor models with marked superiority to comparator ADCs delivering tubulin inhibitors.
| M.Wt | 584.673 | |
| Formula | C33H36N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zammarchi F, et al. Blood. 2018 Mar 8;131(10):1094-1105.
2. Hartley JA, et al. Sci Rep. 2018 Jul 11;8(1):10479.
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