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Chemical Structure : SGI-110
Catalog No.: PC-60765Not For Human Use, Lab Use Only.
SGI-110 (Guadecitabine) is a novel DNA hypomethylating dinucleotide that inhibits DNA methyltransferase (DNMT).
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SGI-110 (Guadecitabine) is a novel DNA hypomethylating dinucleotide that inhibits DNA methyltransferase (DNMT).
SGI-110 induces/up-regulates the expression of investigated cancer/testis antigens in broad cancer cell lines, both at mRNA and at protein levels.
SGI-110 reduces the stem-like properties of ALDH(+) ovarian cancer stem-like cells, including their tumor-initiating capacity, resensitizes these OCSCs to platinum.
SGI-110 induces hypomethylation and CTA gene expression in a dose dependent manner both in vitro and in vivo.
| M.Wt | 557.41 | |
| Formula | C18H24N9O10P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Y, et al. Cancer Res. 2014 Sep 1;74(17):4922-36.
2. Srivastava P, et al. Epigenetics. 2015;10(3):237-46.
3. Srivastava P, et al. Leuk Res. 2014 Nov;38(11):1332-41.
4. Fang F, et al. Clin Cancer Res. 2014 Dec 15;20(24):6504-16.
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