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Chemical Structure : SLLN-15
Catalog No.: PC-36107Not For Human Use, Lab Use Only.
SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation.
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SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation.
SLLN-15 induced a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux, associated with a selective inhibition of AKT-MTOR signaling.
SLLN-15-induced autophagy in TNBC cells was also associated with decreased AURKA expression decreased AKT phosphorylation and subsequent blockage of the AKT-MTOR pathway.
SLLN-15 demonstrates anticancer and anti-metastatic activity in mice bearing TNBC.
| M.Wt | 507.362 | |
| Formula | C19H23N7Se2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang CH, et al. Autophagy. 2019 Feb 17. doi: 10.1080/15548627.2019.1582951.
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