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Chemical Structure : SN-32976
CAS No.: 1246202-11-8
Catalog No.: PC-60392Not For Human Use, Lab Use Only.
SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively.
SN-32976 displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases.
SN-32976 inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.
| M.Wt | 581.64 | |
| Formula | C24H33F2N9O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((4-(4-(2-(difluoromethyl)-4-methoxy-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)sulfonyl)-N,N-dimethylethan-1-amine |
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1. Rewcastle GW, et al. Oncotarget. 2017 May 9. doi: 10.18632/oncotarget.17730.
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