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Chemical Structure : SNX-0723
CAS No.: 1073969-18-2
Catalog No.: PC-60683Not For Human Use, Lab Use Only.
SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $368 | In stock | |
| 10 mg | $568 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
SNX-0723 induces Hsp70 (IC50=31 nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4 nM), ribosomal protein s6 (pS6) (IC50=13 nM), and PERK (IC50=5.5 nM).
SNX-0723 shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties.
| M.Wt | 399.47 | |
| Formula | C22H26FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)benzamide |
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1. Putcha P, et al. J Pharmacol Exp Ther. 2010 Mar;332(3):849-57.et al.
2. McFarland NR, et al. PLoS One. 2014 Jan 20;9(1):e86048.
3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42.
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