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Chemical Structure : ST-148
Catalog No.: PC-35008Not For Human Use, Lab Use Only.
ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein.
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ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.
| M.Wt | 421.537 | |
| Formula | C21H19N5OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Byrd CM, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25.
2. Scaturro P, et al. J Virol. 2014 Oct;88(19):11540-55.
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