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Chemical Structure : STA 2842
Catalog No.: PC-70347Not For Human Use, Lab Use Only.
STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90.
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STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90; induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1(-/-) primary kidney cells and in vivo; significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts.
| M.Wt | 550.66 | |
| Formula | C29H38N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seeger-Nukpezah T, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91.
2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64.
3. Smithline ZB, et al. PLoS One. 2014 Dec 4;9(12):e114403.
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