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Chemical Structure : Saridegib
Catalog No.: PC-62169Not For Human Use, Lab Use Only.
Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM.
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Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM, inhibits Smoothened (Smo).
Saridegib binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO.
Saridegib demonstrates improved pharmaceutical properties and potency and a favorable pharmacokinetic profile relative to cyclopamine and IPI-269609.
Saridegib completely suppresses tumor growth in a Hh-dependent medulloblastoma allograft model.
| M.Wt | 504.768 | |
| Formula | C29H48N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Olive KP, et al. Science. 2009 Jun 12;324(5933):1457-61.
2. Tremblay MR, et al. J Med Chem. 2009 Jul 23;52(14):4400-18.
3. Lee MJ, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7859-64.
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