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Chemical Structure : Seletalisib
CAS No.: 1362850-20-1
Catalog No.: PC-45071Not For Human Use, Lab Use Only.
Seletalisib (UCB-5857) is a potent, ATP-competitive, and selective PI3Kδ inhibitor with IC50 of 12 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Seletalisib (UCB-5857) is a potent, ATP-competitive, and selective PI3Kδ inhibitor with IC50 of 12 nM.
Seletalisib (UCB-5857) shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (204-303 fold).
Seletalisib (UCB-5857) blocks AKT phosphorylation following activation of the B-cell receptor in a B-cell line.
Seletalisib (UCB-5857) blocks human T-cell production of several cytokines from activated T-cells, and inhibits B-cell proliferation and cytokine release.
Seletalisib (UCB-5857) dose-dependently inhibits anti-CD3-antibody-induced interleukin 2 release in mice.
| M.Wt | 482.8451 | |
| Formula | C23H14ClF3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥83.3 mg/mL |
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| Chemical Name/SMILES |
Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]- |
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1. Allen RA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):429-440.
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