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Chemical Structure : Selinexor
CAS No.: 1393477-72-9
Catalog No.: PC-35581Not For Human Use, Lab Use Only.
Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $218 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $758 | In stock | |
| 1 g | Get quote | ||
| 5 g | Get quote |
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Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1).
Selinexor demonstrates in vivo anti-leukaemic efficacy against T-ALL and acute myeloid leukaemia (AML) cells.
Selinexor triggers nuclear accumulation of multiple CRM1 cargo tumor suppressor proteins followed by growth arrest and apoptosis in MM cells, block c-Myc, Mcl-1, and NF-κB activity.
Selinexor (KPT-330, KPT330) induces proteasome-dependent CRM1 protein degradation, upregulates CRM1, p53-targeted, apoptosis-related, anti-inflammatory and stress-related gene transcripts in MM cells.
| M.Wt | 443.313 | |
| Formula | C17H11F6N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide |
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1. Tai YT, et al. Leukemia. 2014 Jan;28(1):155-65.
2. Etchin J, et al. Br J Haematol. 2013 Apr;161(1):117-27.
3. Azmi AS, et al. Gastroenterology. 2013 Feb;144(2):447-56.
4. Walker CJ, et al. Blood. 2013 Oct 24;122(17):3034-44.
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