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Semapimod hydrochloride

Chemical Structure : Semapimod hydrochloride

CAS No.: 164301-51-3

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Semapimod hydrochloride (CNI-1493;AXD-455)

Catalog No.: PC-61901Not For Human Use, Lab Use Only.

Semapimod (CNI-1493, AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) by targeting the TLR chaperone gp96.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Semapimod (CNI-1493, AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) by targeting the TLR chaperone gp96.
    Semapimod does not inhibit EDRF activity, inhibits nitric oxide synthesis by inflammatory macrophages.
    Semapimod prevents the development of carrageenan-induced footpad inflammation, and conferred protection against lethal LPS challenge in mice.

    Physicochemical Properties

    M.Wt 890.746
    Formula C34H56Cl4N18O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1,N10-bis(3-(1-(2-carbamimidoylhydrazono)ethyl)-5-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide tetrahydrochloride

    References

    1. Bianchi M, et al. Mol Med. 1995 Mar;1(3):254-66.

    2. Bianchi M, et al. J Exp Med. 1996 Mar 1;183(3):927-36.

    3. Cohen PS, et al. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3967-71.

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