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Chemical Structure : Sembragiline
Catalog No.: PC-60809Not For Human Use, Lab Use Only.
Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A.
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Sembragiline (RO4602522, RG1577, EVT 302) is a novel potent, selective, orally available monoamine oxidase B (MAO-B) inhibitor with IC50 of 5.9 nM, >600-fold selectivity over MAO-A; displays no affinity for more than 100 different receptors, enzymes and ion channels; protects against neuronal loss and reduces both ROS formation and reactive astrogliosis in transgenic animal model conditionally overexpressing MAO-B in astroglia, exhibits potential for treatment of Alzheimer's disease (AD) and other neurodegenerative disorders.
Alzheimer Disease
Phase 2 Clinical
| M.Wt | 342.37 | |
| Formula | C19H19FN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Borroni E, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):413-423.
2. Nave S, et al. J Alzheimers Dis. 2017;58(4):1217-1228.
3. Yeon SK, et al. Bioorg Med Chem. 2018 Jan 1;26(1):232-244.
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