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Sortase-IN-6e

Chemical Structure : Sortase-IN-6e

CAS No.: 1809545-62-7

Sortase-IN-6e

Catalog No.: PC-70327Not For Human Use, Lab Use Only.

A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM; blocks P2 precursor cleavage by sortase A with IC50 of 68.7 uM in staphylococci; does not affect in vitro staphylococcal growth yet protect mice against lethal S. aureus bacteremia.

Physicochemical Properties

M.Wt 381.36
Formula C14H8N5NaO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

sodium 3-(3-(pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)benzenesulfonate

References

1. Zhang J, et al. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13517-22.

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