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Chemical Structure : T16Ainh-A01
CAS No.: 552309-42-9
Catalog No.: PC-35990Not For Human Use, Lab Use Only.
T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM.
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|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
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| 1 g | Get quote |
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T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM.
T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl−) channels and whole cell currents activated by 500 nM free Ca2+.
T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve.
T16Ainh-A01 blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels.
| M.Wt | 416.514 | |
| Formula | C19H20N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide |
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1. Davis AJ, et al. Br J Pharmacol. 2013 Feb;168(3):773-84.
2. Mazzone A, et al. Biochem Biophys Res Commun. 2012 Oct 19;427(2):248-53.
3. Forrest AS, et al. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1229-43.
4. Namkung W, et al. J Biol Chem. 2011 Jan 21;286(3):2365-74.
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