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Chemical Structure : TAK-243
CAS No.: 1450833-55-2
Catalog No.: PC-60178Not For Human Use, Lab Use Only.
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1) with IC50 of 1 nM.
TAK-243 blocks ssential monoubiquitination events within the translesion synthesis, and homologous recombination (HR) pathways.
TAK-243 shows synergistic and additive anti-tumor combination benefits in vivo combined with carboplatin and docetaxel.
| M.Wt | 519.514 | |
| Formula | C19H20F3N5O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate |
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1. Wei J, et al. J Immunol. 2017 May 15;198(10):3835-3845.
2. Michael A. Milhollen, et al. DOI: 10.1158/1535-7163.
3. Barghout SH, et al. Leukemia. 2018 Jun 8. doi: 10.1038/s41375-018-0167-0.
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