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Chemical Structure : TAK-779
CAS No.: 229005-80-5
Catalog No.: PC-43512Not For Human Use, Lab Use Only.
TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM, antagonizes CCR2b to a lesser extent (27 nM) but does not affect CCR1, CCR3, or CCR4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $258 | In stock | |
| 100 mg | $688 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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TAK-779 is a potent, specific, nonpeptide CCR5 antagonist with Kd of 0.45 nM, antagonizes CCR2b to a lesser extent (27 nM) but does not affect CCR1, CCR3, or CCR4.
TAK-779 also blocks the binding of macrophage inflammatory protein 1α and macrophage inflammatory protein 1β to the cells with an IC50 of 1.0 nM.
TAK-779 TAK-779 displays highly potent and selective inhibition of the replication of macrophage (M)-tropic HIV-1 (Ba-L strain) in both MAGI-CCR5 cells and PBMCs with EC50 of 1.2 and 3.7 nM, respectively.
| M.Wt | ||
| Formula | C33H39ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
2H-Pyran-4-aminium, N-[[4-[[[6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-, chloride (1:1) |
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1. Baba M, Nishimura O, et al. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703.
2. Shiraishi M, et al. J Med Chem. 2000 May 18;43(10):2049-63.
3. Gorry PR, et al. J Virol. 2002 Jun;76(12):6277-92.
4. Nedjai B, et al. Br J Pharmacol. 2015 Apr;172(7):1822-33.
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