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Chemical Structure : TAP-311
Catalog No.: PC-62014Not For Human Use, Lab Use Only.
TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.
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TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM。
TAP-311 displays >170-fold selectivity over CYPs, and has excellent pharmacokinetics in rats and robust efficacy in hamsters。
TAP-311 shows substantially reduced lipophilicity with only modest distribution into adipose tissue, and retains potency in hypertriglyceridemic plasma in vitro and in vivo。
TAP-311 does not increase blood pressure or plasma aldosterone levels in vivo, in contrast to torcetrapib (Cat# PC-42892).
| M.Wt | 710.72 | |
| Formula | C34H40F6N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamada K, et al. J Med Chem. 2017 Oct 26;60(20):8466-8481.
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