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Chemical Structure : TBK1-IN-1
Catalog No.: PC-43042Not For Human Use, Lab Use Only.
TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM.
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TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM; inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.
| M.Wt | 457.5243 | |
| Formula | C26H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 21.5 mg/mL |
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1. Muvaffak A, et al. Mol Cancer Res. 2014 Jul;12(7):1055-66.
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