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TCA-1

Chemical Structure : TCA-1

CAS No.: 864941-32-2

TCA-1 (TCA1)

Catalog No.: PC-70348Not For Human Use, Lab Use Only.

A small molecule with activity against drug-resistant and persistent tuberculosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.

Physicochemical Properties

M.Wt 375.417
Formula C16H13N3O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate

References

1. Wang F, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7.

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