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Chemical Structure : TP-0427736
CAS No.: 864374-00-5
Catalog No.: PC-61454Not For Human Use, Lab Use Only.
TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | $758 | In stock | |
| 100 mg | Get quote |
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TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3.
TP-0427736 inhibits Smad2/3 phosphorylation in A549 cells (IC50=8.7 nM) and decreases the growth inhibition of human outer root sheath cells.
TP-0427736 significantly decreases Smad2 phosphorylation in mouse skin after topical application, may serves as a potential new therapy for AGA.
| M.Wt | 298.382 | |
| Formula | C14H10N4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole |
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1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.
2. Naruse T, et al. Pharmacol Rep. 2017 Jun;69(3):485-491.
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