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Chemical Structure : TRX-0237
Catalog No.: PC-35455Not For Human Use, Lab Use Only.
TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
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TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity; disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways; demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.
| M.Wt | ||
| Formula | C16H19N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harrington CR, et al. J Biol Chem. 2015 Apr 24;290(17):10862-75.
2. Atamna H, et al. FASEB J. 2008 Mar;22(3):703-12.
3. Seripa D, et al. Expert Rev Neurother. 2016;16(3):259-77.
4. Wilcock GK, et al. J Alzheimers Dis. 2018;61(1):435-457.
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