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Tecalcet

Chemical Structure Tecalcet

CAS No.: 148717-54-8

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568)

Catalog No.: PC-62909Not For Human Use, Lab Use Only.

Tecalcet (R-568.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR; potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion (IC50=27 nM in bovine parathyroid cells) without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs.

Hyperparathyroidism

Phase 2 Discontinued

Physicochemical Properties

M.Wt 303.83
Formula C18H22ClNO
CAS No. 148717-54-8
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine

Clinical Information

References

1. Wada MJ Clin Invest. 1997 Dec 15;100(12):2977-83., et al.

2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5.

3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8.

4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.

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