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Chemical Structure : Tenapanor hydrochloride
Catalog No.: PC-63146Not For Human Use, Lab Use Only.
Tenapanor (AZD-1722;RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively.
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Tenapanor (AZD-1722;RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively; displays no inhibitory activities against . human intestinal transporters NHE1 (SLC9A1), NHE2 (SLC9A2), TGR5 (GPBAR1), ASBT and Pit-1; inhibits sodium uptake acted exclusively in the gastrointestinal tract in vivo, reduces extracellular fluid volume, left ventricular hypertrophy, albuminuria, and blood pressure in salt-fed nephrectomized rats, also reduces sodium and phosphorus absorption, protects against vascular calcification in rat model of CKD.
Dyslipidemia
Phase 3 Clinical
| M.Wt | 1217.96 | |
| Formula | C50H68Cl6N8O10S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Spencer AG, et al. Sci Transl Med. 2014 Mar 12;6(227):227ra36.
2. Labonté ED, et al. J Am Soc Nephrol. 2015 May;26(5):1138-49.
3. Zielińska M, et al. Expert Opin Investig Drugs. 2015;24(8):1093-9.
4. Block GA, et al. Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1597-605.
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