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Chemical Structure : Triptolide
CAS No.: 38748-32-2
Catalog No.: PC-45814Not For Human Use, Lab Use Only.
Triptolide (PG490) is the active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Triptolide (PG490) is the active diterpene in the traditional Chinese medicine Lei Gong Teng, induces Ca(2+) release by a polycystin-2 (PC2)-dependent mechanism.
Triptolide (PG490) arrests cellular proliferation and attenuates overall cyst formation by restoring Ca(2+) signaling in a murine model of ADPKD.
Triptolide (PG490) also covalently binds to human XPB (ERCC3), a subunit of the transcription factor TFIIH, and inhibits its DNA-dependent ATPase activity, which leads to the inhibition of RNA polymerase II-mediated transcription.
Triptolide (PG490) inhibits TAK1 kinase activity by interfering with the formation of the TAK1-TAB1 complex in macrophages.
| M.Wt | 360.401 | |
| Formula | C20H24O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)- |
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1. Leuenroth SJ, et al. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94.
2. Titov DV, et al. Nat Chem Biol. 2011 Mar;7(3):182-8.
3. Lu Y, et al. Chem Biol. 2014 Feb 20;21(2):246-56.
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