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Chemical Structure : UK-371804
CAS No.: 256477-09-5
Catalog No.: PC-42335Not For Human Use, Lab Use Only.
UK-371804 is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $108 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $748 | In stock | |
| 250 mg | Get quote |
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UK-371804 is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 10 nM; displays excellent selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin); inhibits exogenous uPA in human chronic wound fluid with IC50 of 0.89 uM; penetrates into pig wounds and inhibits exogenous uPA activity with no adverse effect on wound healing parameters in wound model following topical delivery.
Ulcer
Preclinical
| M.Wt | 385.82594 | |
| Formula | C14H16ClN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl- |
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1. Fish PV, et al. J Med Chem. 2007 May 17;50(10):2341-51.
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