Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Find Your Distributors

Select Your Country or Region

 $ USD

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-p97/VCP-UPCDC30245
UPCDC30245

Chemical Structure : UPCDC30245

CAS No.: 1883351-01-6

Add to Favorites

UPCDC30245 (UPCDC 30245)

Catalog No.: PC-63243Not For Human Use, Lab Use Only.

UPCDC-30245 is a potent, cell penetrant allosteric p97/VCP inhibitor with IC50 of 300 nM (WT p97), also potently inhibits CB-5083 resistant p97 D649A/T688A mutant.

Packing Price Stock Quantity
5 mg Get quote
25 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UPCDC-30245 is a potent, cell penetrant allosteric p97/VCP inhibitor with IC50 of 300 nM (WT p97), also potently inhibits CB-5083 resistant p97 D649A/T688A mutant.
    UPCDC-30245 inhibits proliferation of multiple cancer cell lines, with IC50s ranging from 0.5-4 uM.
    UPCDC-30245 also retains more activity toward CB-5083 resistant HCT116 cell line CB-R-HCT116, harboring p97 double mutant D649A/T688A than does CB-5083, exhibits the same potency in inhibiting the proliferation of CB-R-HCT116 cells as parental HCT116 cells.
    UPCDC-30245 blocks endo-lysosomal degradation by inhibiting the formation of early endosome and reducing the acidity of the lysosome, an effect not observed with the potent p97 inhibitor CB-5083.

    Physicochemical Properties

    M.Wt 463.63
    Formula C28H38FN5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(5-Fluoro-1H-indol-2-yl)phenyl)-N-(2-(4-isopropylpiperazin-1-yl)ethyl)piperidin-4-amine

    References

    1. Segura-Cabrera A, et al. Sci Rep. 2017 Mar 21;7:44912.

    2. Banerjee S, et al. Science. 2016 Feb 19;351(6275):871-5.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: