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Chemical Structure : VTP-43742
Catalog No.: PC-60452Not For Human Use, Lab Use Only.
VTP-43742 (Vimirogant, VTP43742) is a highly potent, selective, oral RORγt inverse agonist with Ki/IC50 of 3.5/17 nM respectively.
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VTP-43742 (Vimirogant, VTP43742) is a highly potent, selective, oral RORγt inverse agonist with Ki/IC50 of 3.5/17 nM respectively.
VTP-43742 exhibits >1,000-fold selectivity versus the RORα and RORβ.
VTP-43742 inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation.
VTP-43742 inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM).
VTP-43742 shows potential for the treatment of autoimmune disorders, including multiple sclerosis and psoriasis.
| M.Wt | 552.657 | |
| Formula | C27H35F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pandya VB, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00588.
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