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Chemical Structure : VU 0240551
CAS No.: 893990-34-6
Catalog No.: PC-62064Not For Human Use, Lab Use Only.
VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
VU 0240551 displays >100-fold selectivity over NKCCl; also shows significant inhibition (>50% at 50 µM) of several GPCRs and key ion channels (hERG and L-Type Ca2+ channels).
| M.Wt | 342.43 | |
| Formula | C16H14N4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide |
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1. Deisz RA, et al. Neuroscience. 2014 Sep 26;277:831-41.
2. Chevy Q, et al. J Neurosci. 2015 Dec 2;35(48):15772-86.
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