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Chemical Structure : VU 0364849
Catalog No.: PC-60768Not For Human Use, Lab Use Only.
VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
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VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
VU 0364849 also inhibits ALK6 (Ki<1 nM) and ALK2 (Ki=42.77 nM), little to no affinity for ALK4/5, BMPR2, AMPK etc.
VU 0364849 blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
| M.Wt | 451.53 | |
| Formula | C27H25N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.
2. Langenfeld E, et al. Mol Cancer. 2013 Oct 26;12(1):129.
3. Langenfeld E, et al. PLoS One. 2013 Apr 12;8(4):e61256.
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