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Chemical Structure : VU 0463271
CAS No.: 1391737-01-1
Catalog No.: PC-62063Not For Human Use, Lab Use Only.
VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.
VU 0463271 displays >100-fold selectivity versus NKCC1 (>100 uM), no significant activities on a panel of 68 GPCRs, ion channels and transporters.
VU 0463271 exhibts 9-times more potent than ML077, and maintains an excellent ancillary pharmacology profile.
| M.Wt | 382.5 | |
| Formula | C19H18N4OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide |
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1. Delpire E, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8.
2. Delpire E, et al. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.
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