Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Vecabrutinib
Catalog No.: PC-50001Not For Human Use, Lab Use Only.
Vecabrutinib (SNS-062) is a potent, reversible, non-covalent BTK inhibitor with IC50 of 2.9 and 4.4 nM for WT BTK and C481S BTK, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Vecabrutinib (SNS-062) is a potent, reversible, non-covalent BTK inhibitor with IC50 of 2.9 and 4.4 nM for WT BTK and C481S BTK, respectively;
Binds to Tec kinase family members BTK (Kd=0.3 nM) and ITK (Kd=2.2 nM), but not bind EGFR, active in vitro in cells with the C481S mutation;
Inhibits pBTK in human whole blood with IC50 of 50 nM, demonstrates favorable pharmacokinetic properties, shows potential for overcoming the ibrutinib resistance due to C481S mutantion in BTK.
Blood Cancer
Phase 2 Clinical
| M.Wt | 529.925 | |
| Formula | C22H24ClF4N7O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
