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Chemical Structure : Verdiperstat
Catalog No.: PC-63145Not For Human Use, Lab Use Only.
Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
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Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.
Spinal Muscular Atrophy (SMA)
Phase 2 Discontinued
| M.Wt | 253.32 | |
| Formula | C11H15N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.
2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.
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