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Chemical Structure : WS-383
Catalog No.: PC-36111Not For Human Use, Lab Use Only.
WS-383 (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
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WS-383 (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2.
WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM.
| M.Wt | 461.991 | |
| Formula | C18H20ClN9S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang S, et al. J Med Chem. 2019 Feb 25. doi: 10.1021/acs.jmedchem.9b00113.
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