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Chemical Structure : WS-383 hydrochloride
CAS No.: 2247544-02-9
Catalog No.: PC-36110Not For Human Use, Lab Use Only.
WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM.
WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27 and NRF2.
WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells, enhances the thermal stability of cellular DCN1 protein even at 1 uM.
| M.Wt | 498.449 | |
| Formula | C18H21Cl2N9S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(5-((2-((4-Chlorobenzyl)thio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio )-1H-tetrazol-1-yl)-N,N-dimethylethan-1-amine hydrochloride |
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1. Wang S, et al. J Med Chem. 2019 Feb 25. doi: 10.1021/acs.jmedchem.9b00113.
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