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Chemical Structure : WZB117
CAS No.: 1223397-11-2
Catalog No.: PC-35327Not For Human Use, Lab Use Only.
WZB117 (WZB-117) is a small-molecule inhibitor of glucose transporter 1 (GLUT1), inhibits glucose transport and cancer cell proliferation with IC50 of 10 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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WZB117 (WZB-117) is a small-molecule inhibitor of glucose transporter 1 (GLUT1), inhibits glucose transport and cancer cell proliferation with IC50 of 10 uM.
WZB117 decreases in levels of Glut1 protein, intracellular ATP, and glycolytic enzymes in treated cancer cells, inhibits cancer growth in tumor-bearing nude mice;.
WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells (CSCs).
| M.Wt | 368.316 | |
| Formula | C20H13FO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate) |
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1. Liu Y, et al. Mol Cancer Ther. 2012 Aug;11(8):1672-82.
2. Liu W, et al. Asian Pac J Cancer Prev. 2014;15(17):7037-41.
3. Shibuya K, et al. Oncotarget. 2015 Jan 20;6(2):651-61.
4. Ojelabi OA, et al. J Biol Chem. 2016 Dec 23;291(52):26762-26772.
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