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Chemical Structure : XCT790
CAS No.: 725247-18-7
Catalog No.: PC-42580Not For Human Use, Lab Use Only.
A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 50 mg | $368 | In stock | |
| 250 mg | $988 | In stock | |
| 1 g | Get quote |
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A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays; shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM; inhibits PGC-1α regulation of ERRα and ERRα target gene expression; inhibits proliferation in cellular models of breast cancer.
| M.Wt | 596.4249 | |
| Formula | C23H13F9N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 21 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]- |
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1. Willy PJ, et al. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7.
2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.
3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.
4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.
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