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Chemical Structure : XR 5118
Catalog No.: PC-62457Not For Human Use, Lab Use Only.
XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion.
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XR 5118 is a small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 3.5 uM, binds to PAI-1 and reduces plasma PAI-1 activity levels, promotes endogenous thrombolysis and inhibits thrombus accretion; the first nonpeptide compound with significant anti-PAI-1 activity in vivo.
Thrombosis
Discontinued
| M.Wt | 435.985 | |
| Formula | C20H22ClN3O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Friederich PW, et al. Circulation. 1997 Aug 5;96(3):916-21.
2. Einholm AP, et al. Biochem J. 2003 Aug 1;373(Pt 3):723-32.
3. Folkes A, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2589-92.
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